rocefin

ROCEPHIN®
(ceftriaxone sodium) for Injection

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Rocephin (ceftriaxone) and other antibacterial drugs, Rocephin (ceftriaxone) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

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DRUG DESCRIPTION

Rocephin (ceftriaxone) is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Ceftriaxone sodium is (6R,7R)-7-[2-(2-Amino-4thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7²-(Z)-(O-methyloxime), disodium salt, sesquaterhydrate.

The chemical formula of ceftriaxone sodium is C₁₈H₁₆N₈Na₂O₇S₃•3.5H₂O. It has a calculated molecular weight of 661.59 and the following structural formula:

Rocephin (ceftriaxone) is a white to yellowish-orange crystalline powder which is readily soluble in water, sparingly soluble in methanol and very slightly soluble in ethanol. The pH of a 1% aqueous solution is approximately 6.7. The color of Rocephin (ceftriaxone) solutions ranges from light yellow to amber, depending on the length of storage, concentration and diluent used.

Rocephin (ceftriaxone) contains approximately 83 mg (3.6 mEq) of sodium per gram of ceftriaxone activity.

What are the possible side effects of ceftriaxone injection (Rocephin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• diarrhea that is watery or bloody;
• fever or chills;
• skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
• blistering, peeling, and red skin rash;
• white patches or sores inside your mouth or on your lips;
• pale or yellowed skin, dark colored urine, confusion or...

Read All Potential Side Effects and See Pictures of Rocephin »

What are the precautions when taking ceftriaxone (Rocephin)?

Before using ceftriaxone, tell your doctor or pharmacist if you are allergic to it; or to other cephalosporins; or to penicillins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: gallbladder disease, kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis).

Avoid giving any products by vein that contain calcium (including solutions such as Ringer's solution, Hartmann's solution, parenteral nutrition-TPN/PPN) to a newborn less than 1 month old who is receiving this medication. Doing so can cause serious problems in the vital..