levopraid

Sulpiride
(Levosulpirida [INN-Spanish], Levosulpiride, Levosulpiride [INN], Levosulpiridum [INN-Latin], Sulpirid, Sulpirida [INN-Spanish], Sulpiridum [INN-Latin], Sulpyrid)

A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
Indication:

Sulpiride is indicated for the treatment of schizophrenia.
Categories:
Antidepressants
Antipsychotics
Dopamine Antagonists
Antipsychotic Agents
Antidepressive Agents, Second-Generation
Mechanism of Action:

In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.
Pharmacology:

Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Other benzamide derivatives include metoclopramide, tiapride, and sultopride.
Absorption:

Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences.
Half Life:

6 to 8 hours
Toxicity:

Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur.
Affected organisms:
Humans and other mammals
Kingdom:
Organic
Type:
small molecule
Group:
Approved
Experimental properties:
logP/hydrophobicity:
0.6
Water Solubility:
2280 mg/L
caco2 Permeability:
-6.16 [ADME Research, USCD]
Brands:
Abilit,
Aiglonyl,
Alimoral,
Calmoflorine,
Championyl,
Coolspan,
Darleton,
Desmenat,
Dobren,
Dogmatil,
Dogmatyl,
Dolmatil,
Dresent,
Eglonil,
Eglonyl,
Enimon,
Equilid,
Eusulpid,
Fardalan,
Fidelan,
Guastil,
Isnamide,
Kylistro,
Levobren,
Levopraid,
Lisopiride,
Mariastel,
Meresa,
Miradol,
Mirbanil,
Misulvan,
Neogama,
Norestran,
Normum,
Nufarol,
Omiryl,
Omperan,
Ozoderpin,
Psicocen,
Pyrikappl,
Pyrkappl,
Restful,
Sernevin,
Splotin,
Stamonevrol,
Sulpitil,
Sulpride,
Suprium,
Sursumid,
Synedil,
Valirem,
Zemorcon
Cas Number:
15676-16-1